The Research Chemical forums and blogs are going into overdrive for a new legal chemical that is going by the name Mexedrone. There rumour mill has been in full swing as to what exactly this new chemical is as we are currently going off very limited information from vendors. Until now RC enthusiasts are relying on small bits of info coming from vendors and forums about it’s effects. While actual information about the chemical formula is yet to be disclosed – It is understood to be an analogue of Mephedrone AKA MCAT, Meow Meow, 4-MMC. Since the ban on Mephedrone in 2010, many people have searched tirelessly for a chemical which could replace that fantastic drug. Well now it seems the wait may be over! We are hesitant to get too carried away however initial trip reports have in general been very encouraging. There have been some reports of it being inactive, however on the whole people have stated that it is very similar but is less potent. Reports have suggested that the potency of Mexedrone is around 2/3 that of MCAT so rather than 60mg doses customers will need to test with 90mg to get that old feeling back. Most people will remain dubious about these claims until they get their own hands on this elusive new compound, however these statements are from respected people so there is hope that finally we could have a viable replacement. It has also been stated that the effect is more euphoric than Mephedrone which will be music to the ears of most chemistry students. Most of the main UK based vendors have now got it listed on their websites and it is now a race to get this sought after chemical in-stock first.
The chemical formula for Mexedrone remains unknown however the smell is said to be very similar to that of Mephedrone which would suggest that it is a cathinone, however UK law has basically banned all cathinones so how the manufacturers have got round this is anybodys guess. There have been people predicting the chemical formula however at the moment none of these predictions have held any substance. Lets just hope that if this chem is as promising as expected it can remain on the right side of the law for as long as possible – especially with the dreaded new UK laws coming into force next April.
One new chemical which has been causing a stir on the Research Chemical scene is the LSD analogue 1P-LSD or 1-propionyl-lysergic acid diethylamide. 1P-LSD was first synthesised in 2015 and as a result it has no history of human usage and no recognition in any academic literature and as a result the effects of 1P-LSD on the human body remains unknown. The main difference between the 2 of them is that while LSD is illegal in nearly every country in the world – 1P-LSD remains completely legal in most of the EU. 1P-LSD is structurally very similar to LSD and AL-LAD and this can often mean it gives very similar effects however things arent always that simple and sometimes while things can look very similar on paper – in reality it just doesn’t work like that. 1P-LSD is available from all the usual Research Chemical vendors starting at around £8 for a blotter. Incase you were wondering 1P-LSD is provided on an ‘acid-like’ paper blotter infused with 100mcg of the active 1P-LSD chemical.
Much like taking acid the paper blotter is placed underneath the tongue for around 15 minutes after which you can swallow it or throw it away. It is often recommended that before taking any new chemical you should conduct what is known as an ‘allergy test’ whereby you use a smaller amount than the recommended dose to check that it doesn’t disagree with your body. Once you have confirmed there is no underlying issue with the compound you can proceed as normal. In the case of this trip report the user tested with half the blotter before using the other half later down the line.
The Trip Report:
“20 Mins after ingestion of the blotter (which I had left under my tongue for around 10-15 minutes beforehand) I start to get a warm fuzzy feeling all over my body and my head is tingling in a nice way, i feel very happy and calm. The sensation is very nice and feels clean unlike some other RC’s ive experimented with in the past which felt kind of scatty and gave a paranoid feeling. At this point I would say I had strong empathetic and euphoric feelings and found myself massaging myself which felt particularly nice. At this point I decide to consume the remaining half of a blotter (100mcg now ingested).
20 Mins later and the feelings are getting more intense but still feeling very positive and relaxed. I am starting to notice patterns throbbing and moving around. Colours appear more vibrant and I find myself staring at innate objects. I pick my phone up and decide to play a game which proves very challenging but extremely fun as I spend most of the time staring at animations and colours rather than actually playing with an objective. After I lose interest in playing games I decide to start watching TV which is hilarious as I find everything funny – i’m in a great place at this point and I cant stop laughing. I found that I could still eat as normal and time would fly by just doing nothing.
After around 5 hours I begin to come down. I’m still feeling really pleasant and chilled, it takes me about an hour and then I fall asleep. Looking back I would say it was a very enjoyable experience and actually really similar to real LSD. No comedown or anything the next day. I would give 1P-LSD 5 Stars out of 5 as it was a really fun experience and it felt clean and there was no bad side effects.”
After the recent removal of Etizolam pellets from most of the Research Chemical Vendors’ shops (as discussed in our previous blog post) we decided to look at the replacements which have cropped up to compare their suitability to take over the crown as King of the Benzos. Since the disapprearance many pellets have been marketed as ‘Etizolam Replacements’ however as ever with these things the replacements are rarely as good as the originals! We have however been very impressed with some of the replacements and we give a run down of the different pellets below:
Deschloro-Etizolam is, as you may have guessed by the name an analogue of Etizolam itself and subsequently was the chemical which was initially presumed to be the best suitor to an Etizolam replacement. The chemical formula is very similar to Etizolam, the only difference being the removal of the chlorine atom from the benzene ring. In theory the fact that it is an analogue of Etizolam it should be the most suitable replacement. The one major difference between the 2 is the quantity needed to get similar results. Whereas Etizolam came in 1mg or 2mg pellets, DeschloroEtizolam requires 6mg or 12mg pellets to do a similar job which means they are significantly more expensive. From my research I also found the Deschloro’s less Euphoric – more of a functional benzo however they did still have good sedative properties.
Replacement Rating: 7
Another chemical which was introduced almost immediately after Etizolam was removed was Nifoxipam. Nifoxipam is an analogue of the benzo Oxazepam and is used to treat anxiety and panic attacks much like Etizolam. Nifoxipam is sold online in 0.5mg and 2mg pellets. We tested both of these pellets from different vendors online and found the 0.5mg pellets absolutely useless – no effect whatsoever. The 2mg pellets were noticeably better however they certainly seemed to lack the sedation properties associated with Etizolam, I would say they were closer to a Pyrazolam pellet. While I think these could come in handy for certain situations I don’t feel they are similar enough to Etizolam to be called an Etizolam replacement. Price-wise they are very similarly priced to the old Etizolams and i’m sure the price will drop on these in the coming months.
Replacement Rating: 4
Next up is Flubromazolam (Not to be confused with Flubromazepam) although it is chemically quite similar to the aforementioned compound. There was some confusion when these were first introduced as one vendor was selling pellets in 0.75mg and 1.25mg doses and then some other major vendors started stocking it in 0.25mg doses. We spoke to some of the vendors in question who assured us that 0.25mg was more than enough to be a very interesting pellet. We purchased some of these 0.25mg pellets and must say they weren’t wrong. These are some of the most potent benzodiazepine pellets we have studied, the fact that there is only 1/4 of a mg!! in each pellet shows just how potent this compound is. Effects-wise it is very similar to Etizolam – even someone with a high tolerance to benzos found these pellets very effective. I would say their hypnotic effects outweigh Etizolam and they are active for a similar amount of time (6/7 hours) and for a starting price of £5 for 10 pellets these really are fantastic value.
Replacement Rating: 10
Finally the last chemical we are reviewing is Clonazolam which is an analogue of the pharmaceutical drug Clonazepam. Clonazolam is sold online in measures of 0.5mg per pellet. We purchased these online for around £8 for 10 so slightly more expensive than the Flubromazolam but still well priced – similar to 1mg Etizolam. These pellets really were great – similar on a variety of parameters to Etizolam however the peak results lasted longer than Etizolam. Not as sedative as Etizolam or Flubromazolam but really fun to study – similar to Xanax but with a longer half-life. Not quite as similar to Etizolam as Flubromazolam which is why the score is not a 10, however an amazing new benzodiazepine in it’s own right. Probably my favourite benzo right now check these out if you haven’t already.
Replacement Rating: 9
Regular Research chemical shoppers will most likely have noticed the gradual disappearance of Etizolam from the shelves of many of the most popular online RC Vendors. For those of you who are unfamiliar with this compound it is a benzodiazepine derivative that is sold over the counter in India as a skeletal relaxant. It is used to treat conditions such as anxiety, amnesia and panic attacks. Due to the fact that Etizolam is not listed as a medicine is much of Europe it has up until now been freely sold online in the form of a ‘research chemical’ AKA not for human consumption. Etizolam has been the most popular Research Chemical on the market now for the last couple of years due to its flexibility and ease of use. It was originally sold in professionally packed blister packs direct from Indian pharmaceuticals although many vendors stopped this due to the packaging which implied use as a medicine which contradicted the companies conditions of sale. It seems however that the sale of this extremely popular benzo has been discontinued on many of the main vendors websites so why is this?
We have asked a few stores why they have stopped selling Etizolam because as far as we are aware there has not been a ban on Etizolam in the UK. Some vendors seemed uneasy at the question – clearly treading carefully around the subject however we did get some information from an un-named vendor who told us that the legality of Etizolam in the UK has come under some scrutiny. While it is not listed as a medicine in the UK it is apparently listed as a medicine in Italy and the laws surrounding medicine in the EU reportedly state that if a chemical is listed as a medicine in any EU country it is classed as a medicine in the rest of the EU. This would explain the sudden disappearance of Etizolam without warning.
We have however also received an email from one vendor stating that they are continuing selling Etizolam because it is not illegal and has not been banned so it seems there is still confusion surrounding this chemical. Whether these vendors legitimately believe it is completely legal or whether they are simply continuing to sell it so that they don’t lose custom is still unknown but there is clearly some confusion over this product and many vendors nowadays will air on the side of caution when it comes to the legality of Research Chemicals.
The UK’s longest running research chemical shop Plant Food Palace has rebranded as Science Supplies Direct. While it is a shame to see the back of such an iconic brand we feel it is a good move for the guys and helps make them a more serious research chemicals vendor. They seem to be stocking a much wider selection of science supplies including gloves, aprons and goggles so this certainly makes them the UK’s most varied science and research chemicals store. They also have a promotion on using the code sciencesuppliesdirect for a 10% discount. There is a also talk that this rebrand will enable the company to take larger credit & debit card payments and reduce fraud. We personally love the new brand and wish them all the best.
The ACMD has reported back to the government to advise that they put a permanent ban on a selection of research chemicals as a result of an investigation into their misuse. The most notable of those products which are due to be controlled is that of 5-EAPB which is widely available in most good Research Chemical stores. This compound has been added to other benzofurans 5-APB & 6-APB as well as 5-MAPB which were placed under temporary control last June. In hindsight it was probably a poor move by the vendors who released 5-EAPB so quickly after the banning of the other Benzofurans as it gave the authorities the ability to easily add this interesting material to their ban list. The ban is due to come into force in spring this year and it will be a disappointment for many as 5-EAPB is quite unique in the current market which is saturated with stims and benzo’s. The recommendation suggests that these chemicals be listed as Class B Drugs.
A couple of other compounds which are due to be scheduled include some less known compounds such as 5-IT which is not widely stocked anymore due to concerns over it’s safety, and IAP which is another less known chemical. There was also a seperate report published which deals with the NBOME family of chemicals although these have also never really taken off due to their hazardous potency.
These materials are due to come into force on June 10th 2014 so all websites will likely be running special promotions in the build up to this ban. If you would like to read more about the law change you can read the report here.
Diclazepam Pellets: The newest benzo on the block
Diclazepam is a benzodiazepine based chemical which has recently entered the research chemical market in the form of small pressed pellets which commonly contain 1mg or 2mg of active Diclazepam. You may have guessed from it’s uncannily similar name that Diclazepam is an analogue of the pharmaceutical drug Diazepam which is used to treat patients suffering from Insomnia, Panic Attacks, Anxiety and Seizures. This close similarity has led to a vast interest in this new compound for all people suffering from these symptoms as well as scientists looking into the possibilities of this new chemical material. Early indications suggest that 1mg of Diclazepam is equivalent to 10mg of Diazepam.
If you are wanting to buy Diclazepam online you can currently get 10 pellets for £9.50 from UK-based research chemical supplier Plant Food Palace as well as many other vendors across the web. The purchase of Diclazepam or 7-chloro-5-(2-chlorophenyl)-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one is currently legal to possess and import throughout the whole of the EU without the need for a home office license. This will be of particular interest to customers in countries where the other popular benzodiazepine-based research chemical Etizolam is no longer unscheduled. We must point out that anyone purchasing Diclazepam is doing so on the condition that they are only using it as referencing sample and not for any in-vivo studies.
Those of you who closely follow the movements of the Research Chemical industry or those of you who study research chemicals will be aware of the recent introduction of a new APB by the name of 5-EAPB. This new compound is an amphetamine which is structurally very similar to 5-APB 5-(2-aminopropyl)benzofuran and 5-MAPB 1-(benzofuran-5-yl)-N-methylpropan-2-amine. 5-APB and 5-MAPB, as well as 6-APB and 6-MAPB were included in a recent Temporary Class Drug order issued by the Home Office on June 10th. The banning of these compounds came as a big shock to the industry where these fascinating Benzofurans had been setting the benchmark in research chemicals for years. Benzo Fury had been making newspaper headlines for months – firstly after a girl proclaimed that she had swallowed one of the Benzo Fury Pellets and walked around naked in a frenzy. And after a second incident whereby a man died at a popular Scottish festival after apparently consuming a Benzo Fury Pellet. These sensationalised and unfounded stories brought these chemicals to the public eye and alerted government bodies to the presence of this particular research chemical. Subsequently we have found out that the teenager who had apparently died from consuming Benzo Fury had not taken benzo fury but had in-fact taken ‘dodgy’ ecstasy pill (MDMA). Without any serious studies being done into the safety of Benzo Fury (6-APB) the compound was added to the Temporary Class Drug Order list. The related compounds 5-APB and 5-MAPB were also added in what was one of the biggest shocks to the community for years.
Following on from these bans there was a fear that these seemingly rushed draconian measures would leave a massive void in the research chemical industry however just 3 days after the ban Purechemicals.net decided to launch 5-EAPB. 5-EAPB is an N-Ethyl derivative of 5-APB and as a result it falls outside the temporary ban. The pricing of 5-EAPB is currently at a premium like is often the case when a new compound first surfaces, being widely listed at £50 a gram however the price will almost certainly drop dramatically over the coming months. Early indications from around the blogosphere suggest that 5-EAPB is a particularly exciting compound which will be a more than suitable replacement for the banned APB’s. Everyone involved in the research chemical industry is just hoping that the home office puts more thought into the deployment of any future TCDO’s.
We are often asked by newbies to the world of cannabinoids how to make your own herbal incense blend infused with their choice of cannabinoid. Making your own blend is very easy and can save you a load of money however it can be time consuming and takes a couple of days before it can be ready to smoke. Many people will prefer to pay extra for the convenience of buying a pre-made blend, if you are one of these people we recommend Plant Food Palace whose popular blends MIST and Strawberry SENSI are the best ones we’ve tried and are some of the cheapest online. The potency of your blend will vary depending on how accustomed you are to smoking cannabinoids and the cannabinoid you are using. Cannabinoids can vary in potency quite drastically so please take care not to overdo it.
What you will need:
- A large tub/container
- A bottle of 100% Pure Acetone
- A large spoon/stirrer
- Your choice of cannabinoid
- Your choice of herb (Damiana Leaf & Marshmallow Leaf work well)
- (Optional) Tobacco flavouring such as “Tasty Puff” plus a fine mist spray bottle.
- Remove the twigs from the herbs, the amount of sticks and twigs will vary from herb to herb – Damiana Leaf for example is very twig-heavy however Marshmallow leaf has very few twigs
- weigh out your herbs and your choice of cannabinoid. You may choose to combine herbs as they all differ in harshness so by combining a few you can achieve your desired smoke. If you are unsure of the ratio of cannabinoid to herb to use please refer to our chart below:PB-22 / BB-22: Potent – 1g Chem to 35g Herb Medium – 1g Chem to 40g Herb Mild – 1g Chem to 50g Herb
Potent – 1g Chem to 17g Herb Medium – 1g Chem to 25g Herb Mild - 1g Chem to 35g Herb
STS-135 / 2NE1
Potent - 1g Chem to 15g Herb Medium – 1g Chem to 20g Herb Mild – 1g Chem to 25g Herb
- Pour enough Acetone into the basin/tub to moisten all the herb but not too much so that the herbs will be soaked as it will take a long time to dry out. Pour roughly 1 cup of acetone for 200g of herb. Then stir thoroughly so that all the herbs go a dark colour, signifying that they are wet.
- Leave to dry in a well ventilated, warm and dry room.
- Once the smell of acetone has completely disappeared and the blend smells solely of herbs your blend is ready. At this stage you can spray your blend with your chosen flavouring using a fine “mist” spray to evenly distribute the flavouring.
Since the UK’s legislation was amended on February 2013 in an attempt to combat the widespread legal use of synthetic cannabinoids the market has been quick to respond. Just 2 months after the ban there are already a handful of new synthetic cannabinoids which remain legal post-ban. The Home Office document outlined a blanket ban on all cannabinoids containing an indole element within their formula. This covered the vast majority of synthetic cannabinoids – The AM Series AM-2201, AM-694, AM-1220, AM-2233 as well as popular cannabinoids MAM-2201 & UR-144. The European market was quick to evolve however as the US constitution’s tight narcotics laws had already led to replacements being synthesised in China which did not contain an indole element. Step forward the Indazole-based synthetic cannabinoids. These new wave of synthetic cannabinoids are based around an indazole ring as opposed to an indole ring which makes them completely legal throughout the UK and Europe. The new compounds which have been released so far include AKB-48, PB-22, 2Ne1, BB-22 plus their fluorinated counterparts 5F-AKB-48, 5F-PB-22 and STS-135 – and they are all legal to acquire without the need for a home office license. We give a lowdown of some of these new compounds below:
Systematic (IUPAC) name: 1-pentyl-N-tricyclo[126.96.36.199,7]dec-1-yl-1H-indazole-3-carboxamide
CAS number 1345973-53-6
Mol. mass 365.510 g/mol
2NE1 / APICA
Molecular Mass: 364.522 g/mol
Molecular Formula: C24H32N2O
CAS number: 1400742-17-7