Since the UK’s legislation was amended on February 2013 in an attempt to combat the widespread legal use of synthetic cannabinoids the market has been quick to respond. Just 2 months after the ban there are already a handful of new synthetic cannabinoids which remain legal post-ban. The Home Office document outlined a blanket ban on all cannabinoids containing an indole element within their formula. This covered the vast majority of synthetic cannabinoids – The AM Series AM-2201, AM-694, AM-1220, AM-2233 as well as popular cannabinoids MAM-2201 & UR-144. The European market was quick to evolve however as the US constitution’s tight narcotics laws had already led to replacements being synthesised in China which did not contain an indole element. Step forward the Indazole-based synthetic cannabinoids. These new wave of synthetic cannabinoids are based around an indazole ring as opposed to an indole ring which makes them completely legal throughout the UK and Europe. The new compounds which have been released so far include AKB-48, PB-22, 2Ne1, BB-22 plus their fluorinated counterparts 5F-AKB-48, 5F-PB-22 and STS-135 – and they are all legal to acquire without the need for a home office license. We give a lowdown of some of these new compounds below:
AKB-48
Systematic (IUPAC) name: 1-pentyl-N-tricyclo[3.3.1.13,7]dec-1-yl-1H-indazole-3-carboxamide
Identifiers
CAS number 1345973-53-6
Chemical data
Formula C23H31N3O
Mol. mass 365.510 g/mol
2NE1 / APICA
IUPAC: -pentyl-N-tricyclo[3.3.1.13,7]dec-1-yl-1H-indole-3-carboxamide
CAS#: 1345973-50-3
Molecular Mass: 364.522 g/mol
Molecular Formula: C24H32N2O
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PB-22
CAS number: 1400742-17-7
Formula: C23H22N2O2








